Exact Sciences Corporation

Quality Control Variant Review Scientist

Job Locations US-Remote
Req No.
Clinical Lab Operations
Regular Part-Time

Summary of Major Responsibilities

The Quality Control, Variant Review Scientist will perform quality control and result review of the next generation sequencing (NGS) output files generated by the laboratory’s proprietary analysis software. The position will also partner with the evidence team, Bioinformatics, R&D, and IT teams to collaborate and assist in database maintenance and development activities. 


The position will also serve as an Assistant Technical Supervisor (CLIA) in the clinical laboratory and must be accessible to the laboratory as needed for on-site, telephone, or electronic consultation and is responsible for the technical and scientific oversight of the laboratory, and performing and recording competency assessment for high complexity testing.  

Essential Duties and Responsibilities

  • Develops expertise in interpreting variant data using proprietary analysis software and open source databases.
  • Participates in the review of variant data and supports the evidence team in the maintenance of the active knowledgebase for variant interpretation.
  • Assists in variant database curation strategies; which may include variant scoring process, interpretation process, and reporting process on an ongoing basis.
  • Participates in extensive literature review and provides input and collaborates with scientists, medical team, lab medical directors, and technologists in interdepartmental activities for ongoing technical education.
  • Strong teamwork and strong interpersonal skills.
  • Excellent verbal and written communication skills.
  • Strong organizational and documentation skills suitable to a clinical laboratory environment. 
  • Comfortable using a variety of computational databases to aid in the interpretation of genomic variants. 
  • Ability to work independently. 
  • Ability to prioritize and work under tight deadlines. 
  • Uphold company mission and values through accountability, innovation, integrity, quality, and teamwork.
  • Support and comply with the company’s Quality Management System policies and procedures.
  • Regular and reliable attendance.
  • Ability to work the mutually agreed schedule established each week.
  • Ability to work nights and/or weekends as needed.
  • Ability to work on a mobile device, tablet, or in front of a computer screen and/or perform typing for approximately 90% of a typical working day.
  • Considerable periods of time may be spent concentrating and or analyzing data.


Minimum Qualifications

  • Doctoral degree in Chemical, Physical, Biological or Clinical Laboratory Science from an accredited institution with specialized training and/or appropriate experience in molecular pathology.
  • 2+ years of experience in Oncology or related field.
  • 1+ years of laboratory training and/or experience in high complexity testing.
  • Demonstrated ability with next-generation sequencing methods and data analysis.
  • Demonstrated ability in somatic/genetic variant interpretation for oncology based NGS tests. 
  • Demonstrated ability in molecular biology methods and data analysis.
  • Demonstrated ability to rapidly distill concise and succinct summaries from complex and potentially contradictory literature sources.
  • Authorization to work in the United States without sponsorship.
  • Demonstrated ability to perform the Essential Duties of the position with or without accommodation.

Preferred Qualifications

  • Molecular fellowship and board eligibility towards FACMG certification, valid FACMG certification or ABMGG certification.
  • Previous experience working in a diagnostic clinical laboratory.
  • Experience reviewing medical literature and pathology reports.


We are an equal employment opportunity employer. All qualified applicants will receive consideration for employment without regard to age, color, creed, disability, gender identity, national origin, protected veteran status, race, religion, sex, sexual orientation, and any other status protected by applicable local, state or federal law. Applicable portions of the Company’s affirmative action program are available to any applicant or employee for inspection upon request.


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