Exact Sciences Corporation

Associate Scientist, Biomarker Research

Job Locations US-AZ-Phoenix
Req No.
Research & Development
Regular Full-Time

Summary of Major Responsibilities

The Associate Scientist, Biomarker Research supports the day-to-day project development activity through interaction with scientists and/or contractors, while gathering, analyzing, and interpreting scientific data. The Associate Scientist, Biomarker Research evaluates literature research data, provides administrative support to the Director, Biomarker Research & Evidence, and self-manages projects as assigned.


In particular, the Associate Scientist, Biomarker Research is responsible for the exploration and implementation of biomarker candidates that may be used to guide treatment selection and/or may become part of the Paradigm biomarker portfolio. This includes the fast track exploration of emerging clinical markers, the conceptualization of biomarker evaluation packages for the Evidence Review Committee, as well as the translation of approved target-drug associations into the Paradigm proprietary rules interface.


As part of the biomarker research group, the Associate Scientist integrates basic and clinical science studies along with computational, statistical and epidemiologic approaches for a comprehensive understanding of biomarkers and their associations with disease processes. The ideal candidate has a good understanding of basic, translational and clinical research, as related to the treatment of cancer as well as proteomic and molecular profiling of cancer and molecular targets, pathways that may be targeted with relevant immunologic or molecular therapies, and the evolving role of biomarkers in precision oncology clinical trials.

Essential Duties and Responsibilities

  • Supports quality assurance for outgoing patient reports; specifically related to the interpretation of evidence-based oncology biomarkers for therapeutic decision-making.
  • Supports translation of novel biomarkers into clinical practice by surveying published literature, as well as clinical trial data from discovery to preclinical, clinical, and post-approval trials (real time evidence maintenance).
  • Monitors validated target drug associations for personalized cancer diagnostics by providing cutting-edge knowledge transfer from bench to the bedside.
  • Participates in the management of biomarker archives and biomarker-specific evidence dossiers, as well as updating the literature repository for continuous biomarker maintenance and exploration of novel targets.
  • Supports efforts in technology transfer/convergence between the biomarker research group, lab personnel and IT.
  • Reports surveillance and quality assurance for outgoing patient reports.
  • Uphold company mission and values through accountability, innovation, integrity, quality, and teamwork.
  • Support and comply with the company’s Quality Management System policies and procedures.
  • Regular and reliable attendance.
  • Ability to work independently and make decisions.
  • Clear communication and ability to speak, read and write in English.
  • Standing or sitting for long periods of time may be necessary.
  • Some lifting (greater than 25 pounds) may be necessary.
  • Use of computer and some time may be spent concentrating, reading, or analyzing data, or applying scientific rules.
  • Manual dexterity, bend, reach, and stoop.
  • Ability to coordinate information and activities.
  • Ability to prioritize and manage multiple projects simultaneously.
  • Ability to perform mathematical calculations.
  • Ability to function in a fast-paced environment.
  • Ability to meet critical deadlines.
  • Teamwork oriented, and projects a positive interaction with outside agencies.


Minimum Qualifications

  • PhD, MD, DO, or PharmD in Molecular and Cellular Biology, Biochemistry, Cancer Biology, or other related field.
  • 1+ years of experience in basic, translational, and clinical research related to proteomic and molecular profiling of cancer specimen, treatment of cancer patients and/or clinical trials.
  • Ability to use literature review as a method to synthesize research in precision oncology.
  • Authorization to work in the United States without sponsorship.
  • Demonstrated ability to perform the Essential Duties of the position with or without accommodation.

Preferred Qualifications

  • PhD preferred.
  • A background in clinical data interpretation and/or evidence-based medicine experience.

We are an equal employment opportunity employer. All qualified applicants will receive consideration for employment without regard to age, color, creed, disability, gender identity, national origin, protected veteran status, race, religion, sex, sexual orientation, and any other status protected by applicable local, state or federal law. Applicable portions of the Company’s affirmative action program are available to any applicant or employee for inspection upon request.


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